Antidepressants and Alcohol

Antidepressants' Interactions and Side Effects

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Simultaneous use of drugs and alcohol, sometimes can lead to unpredictable consequences. It is not recommended to take Alcohol with any medication, it intensifies side effects and provokes their occurrence. Ethanol is extremely dangerous when patient is taking tranquilizers or antidepressants.

Recommendations for the simultaneous administration of Fluoxetine and ethanol, compatibility of these substances are contained in the leaflet to the medication: during treatment patient should refrain from taking alcohol.

An extensive consultation on taking a medication and alcohol can be taken from a treating doctor, it is extremely important to carry out his advice, since it is very dangerous to combine the drug with ethanol during the treatment period.

Fluoxetine and alcohol, when used together, cause symptoms of increased serotonin levels in the blood, hypertension of the serotonin system, serotonin syndrome expressed in severe agitation, hypomania, confusion, delirium, whole body tremor, diarrhea, tachycardia, hypertension, fever, agitation, hypertension muscle, acute myocardial infarction, cardiorespiratory disorders.

Fluoxetine combined with alcohol is often a source of oppression of the respiratory center, which leads to the cessation of breathing, death. So, alcohol cravings during taking Fluoxetine are harmful.

After the end of the 3-week therapy with the drug and its withdrawal, Fluoxetine stays in the body for 7-9 days, Fluoxetine is excreted from the body by the liver and kidneys. The constant concentration of drug in the blood is reached after 28 days of regular use of the drug. With prolonged continuous therapy from 1.5 months or more, the drug can be in the body for up to 2-3 months. This means that for the entire specified period, Fluoxetine, even after withdrawal at any time, can show its actions.


Pharmacological Properties

Fluoxetine is an antidepressant for oral administration, selectively and reversibly inhibits the reverse neuronal seizure of serotonin.

It helps to improve mood, eliminates feelings of fear and tension, dysphoria. Has no sedative effect. Does not have cardiotoxic action. A persistent clinical effect develops after 3-4 weeks of continuous intake.

Fluoxetine 20mg Indications

Various types of depression (especially depression accompanied by fear), including - resistant to treatment with other antidepressants, obsessive-phobic disorders, bulimic neurosis (to reduce appetite and weight loss).


Fluoxetine 20mg is prescribed to adults only. The usual dose for depression is 20 mg once a day. If necessary, after 3-4 weeks, increase the dose by 20 mg / day. The maximum daily dose is 80 mg.

People elderly and senile age are prescribed in a dose not exceeding 60 mg / day.

With a single application (20 mg), the drug is taken in the morning, twice in the morning and in the evening.

The course of treatment should be quite long (2-3 months).

Side Effects when taking Fluoxetine and alcohol

  • Asthenia;
  • Increased sweating;
  • Nausea;
  • Diarrhea;
  • Anorexia;
  • Dyspepsia;
  • Vomiting;
  • Dry mouth feeling;
  • Headache;
  • Dizziness;
  • Increased excitability;
  • Insomnia;
  • Tremor;
  • Fatigue;
  • Seizures;
  • Mania and hypomania;
  • Pharyngitis;
  • Dysphonia;
  • Bronchitis;
  • Allergic and immunopathological reactions;
  • Sexual disorders (increased libido, weakening of orgasm or anorgasmia);
  • Rarely - hyponatremia;
  • Individuals continuously in combination therapy with diuretics.


Simultaneous use with MAO inhibitors is prohibited. After the end of the administration of MAO inhibitors, Fluoxetine may be administered no earlier than 14 days. Before starting the use of MAO inhibitors should pass at least 5 weeks after taking Fluoxetine. It is advisable to use caution when using Fluoxetine and other psychotropic drugs: lithium preparations (possibly both an increase and a decrease in plasma concentration in the blood), tricyclic antidepressants, tryptophan preparations.

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